
Stimulate Growth with ZYP Peptide Therapy.
Peptide therapies that promote longevity.
Sermorelin
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Potential Uses & Benefits include:
• Stimulates physiologic pulsatile secretion of growth hormone
• Promotes growth in most cells including muscle
• Modulates hypogonadal symptoms
• Stimulates FSH and LH release
• Signals liver production of IGF-1
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Pharmacology
• Sermorelin stimulates the pituitary gland and pituitary receptors to increase production and secretion of endogenous human growth hormone (hGH)
• Stimulates pituitary gene transcription of human (hGH) messenger RNA, increasing pituitary reserve supply of (hGH)Mechanism of Action
• Mimics GHRH
• Stimulates release of GH and liver IGF-1 -
Adverse Effects >10%
Facial flushing; headache, nausea, pain, redness, or swelling at injection site, paleness, strange taste in mouth, vomiting.
Warnings and Precautions
There is a link between raised IGF-1 levels and risk for some types of cancer* (1)
1. Knuppel, A., Fensom, G., Watts, E., Gunter, N., Papier, K., Perez-Cornago, A., Schmidt, J., Smith Byrne, K., Travis, R., Key, T. Circulating Insulin-like Growth Factor-1 Concentrations and Risk of 30 Cancers: Prospective Analysis in UK Biobank. Cancer Res (2020) 80 (18): 4014–4021. -
• Avoid use in pregnant or breastfeeding women
Tesamorelin
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Potential Uses & Benefits
• Improves Cognitive Function
• Anti-Aging Effect
• Weight Loss
• Better Sleep Quality
• Increase Lean Muscle Mass
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Mechanism of Action
• Stimulates the synthesis and release of endogenous GH, with an increase in level of insulin-like growth
factor (IGF-1)
• The released GH then binds with the receptors present on various organs in the body and regulates
the body composition (reducing fat tissue and increasing lean muscle mass)
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Side Effects
• Headache
• Dizziness
• Injection site reactions
• Shortness of breath
• Fluid retention or swelling (possible GHRH class side effect)
• Muscle pain or stiffness
• Changes in blood sugar levels
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Contraindications:
• Pituitary gland tumor, has had pituitary gland surgery, other problems related to their pituitary gland, or
has had radiation treatment to their head or a head injury
• Active cancer
• Pregnant patients
Warnings and Precautions:
• Increased risk of neoplasms (cancer)
• Increased mortality in patients with acute critical illness
• Reduced reproductive and fertility rate
• Glucose intolerance or diabetes mellitus may develop. Evaluate glucose status prior to and during therapy
NAD+
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Potential Uses and Benefits
• Increased Energy and Mental Clarity
• Improved Athletic Performance
• Support Metabolism
• Repair Damage to Cells and DNA
• Combat Inflammation
• Anti-Aging
• Increase Lean Muscle Mass
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Mechanism of Action
• NAD+ is broken down to NAM by poly(ADP-ribose) polymerases (PARPs), sirtuins, and a family of ADP-ribose transferases (ARTs), to which NAM exerts feedback inhibition
• Among these, inhibition of PARPs constitutes an important route of anti-inflammatory, anti-oxidative, and pro-cell survival effects.
• Increased level of NAD+ activates sirtuin proteins which exert a variety of cell-beneficiary effects such as anti-oxidation, genome stability, autophagy, and lipid metabolism
• In addition, increased NAD+ levels maintain mitochondria quality and integrity and keep reactive oxygen species (ROS) generation at low level
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• Injection site reactions (SubQ)
• Nausea
• Headache
• Shortness of breath
• Constipation
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Contraindications:
• Pregnant and breastfeeding women
• Children